More evidence for dopaminergic involvement during avoidance learning in depressive adolescents

We are very happy that our new article has been published in Biological Psychiatry: CNNI! In our new article, we show that adolescent MDD is related to impaired processing of error signals during loss in the orbitofrontal cortex, which might reflect an early mechanism of helplessness in the brain.

• Willinger, D., Karipidis, I. I., Neuer, S., Emery, S., Rauch, C., Häberling, I., … & Brem, S. (2021). Maladaptive avoidance learning in the orbitofrontal cortex in adolescents with major depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.